The bacteria in Azodyl work best in the colon region of the intestine. The harsh environments of the stomach and small intestine are detrimental to the bacteria. Consequently, we have to encapsulate them to ensure the maximum number of bacteria reach the colon.

There are a number of studies. BUN and creatinine reduction has been observed in a pig model study. The results of clinical evaluation in client owned cats were recently reported in “The Journal of Veterinary Holistic Medicine”. Additional studies are underway.

Depending on the overall health state of the animal the reduction in BUN and creatine can occur as soon as two weeks but certainly we can see a reduction by the time of the next re-check (usually 1 month)

As these are viable organisms we recommend that it be keep refrigerated at all times. We store under refrigerated conditions and ship using coolers and freezer packs. our distributors keep it stored under those conditions. A clinical study showed that the bacterial counts were stable at -20, 4 and 25 degrees Centigrade (C) for up to 14 days. The counts decreased at 37, 45, and 55 degrees C. The urea hydrolytic activity remained at least at 50% even under the 45 degree conditions. We recommend refrigeration as we are concerned that there may be a cumulative effect of temperature elevations over time. These temperatures are: 4C=39.2 Fahrenheit (F), -20C=-4F, 25C=77F, 37C=99F, 45C=113F, 55C=131F.

We have no reported side effects except for a case of vomiting and two cases of diarrhea. These may be attributed to the concurrent CKD effects on the body. Re-establishing the normal gut microflora may have accounted for the upsets. If AZODYL is suspected we recommend reducing the does and continue observing the patient.